Sexual Health

At Ascend Rx, we support prescribers and patients through prescription compounding, which may be considered when a commercially available medication is not suitable for example, due to needed dose adjustments, dosage-form preferences, or ingredient sensitivities. Compounded medications are prepared only pursuant to a valid prescription, and therapy should be individualized and monitored by a doctor.

Compounded Options at Ascend Rx Sildenafil Citrate (PDE5 inhibitor)

A prescription medication commonly used for erectile dysfunction. Compounding may be considered when a prescriber requires a specific strength or dosage form, or when ingredient sensitivities limit use of a commercial product. Important safety considerations (including interactions with nitrates and cardiovascular risk) should be reviewed by the prescriber.

Sildenafil Citrate + Testosterone (combination compound)

A prescriber-directed compounded option that may be considered in select patients where clinicians are addressing more than one contributing factor to sexual function. Testosterone therapy requires careful clinical assessment and monitoring, and appropriate patient selection is important.

TriMix (Alprostadil + Papaverine + Phentolamine) - Sterile

A sterile, prescription-compounded intracavernosal injection therapy that may be considered for erectile dysfunction, typically when oral therapies are not effective or not appropriate. It requires clinician guidance, proper training, and clear safety counseling (including the risk of prolonged erection/priapism).

Topical DHEA (VAGINAL CREAM)- Nonsterile Topical

A prescriber-directed topical compounded option sometimes considered for sexual wellness concerns. Evidence varies by ingredient and route; for example, intravaginal prasterone (DHEA) has FDA-approved labeling for postmenopausal dyspareunia, while other topical combinations may have more limited evidence.

Topical Arginine HCL + Ergoloid Mesylate + Pentoxifylline + Sildenafil + Testosterone 1 mg/g Cream - Nonsterile Topical

A customized topical compounded formulation. This is a highly individualized compound where prescribers weigh patient-specific goals, tolerability, and potential systemic absorption/interaction risks. Because evidence can vary by ingredient, dosing, and route, it should be used only under a licensed prescriber’s direction with appropriate monitoring.

Go beyond the stigma—talk to your doctor about sexual health concerns and the most appropriate options for you.
Important Notes

All Ascend Rx compounded medications are prepared only pursuant to a valid prescription. Compounded drugs are not FDA-approved; treatment is individualized and should be monitored by the prescribing licensed doctor.

References

1. World Health Organization. Sexual health. WHO website. Accessed December 22, 2025.

2. U.S. Food and Drug Administration. Compounding and the FDA: Questions and Answers. Updated September 16, 2025. Accessed December 22, 2025.

3. Burnett AL, Nehra A, Breau RH, et al. Erectile Dysfunction: AUA Guideline. J Urol. 2018;200(3):633-641. doi:10.1016/j.juro.2018.05.004.

4. Bhasin S, Brito JP, Cunningham GR, et al. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744. doi:10.1210/jc.2018-00229.

5. DailyMed. Sildenafil tablets, prescribing information (contraindications include nitrates). Updated June 23, 2025. Accessed December 22, 2025.

6. U.S. Food and Drug Administration. CAVERJECT (alprostadil) for injection — prescribing information (prolonged erection/priapism warning). 2017. Accessed December 22, 2025.

7. U.S. Food and Drug Administration. INTRAROSA (prasterone) vaginal insert — prescribing information. 2016. Accessed December 22, 2025.

Disclaimer
*This site is intended as a source of general health information.
Each patient and health condition is unique, it’s imperative you consult with your doctor for medical advice to determine if a particular treatment is right for you.
*Only a licensed healthcare practitioner or patient with a valid prescription can order compounded medication.
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